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CH40206: Topics in organic chemistry II

[Page last updated: 23 October 2023]

Academic Year: 2023/24
Owning Department/School: Department of Chemistry
Credits: 3 [equivalent to 6 CATS credits]
Notional Study Hours: 60
Level: Masters UG & PG (FHEQ level 7)
Period:
Semester 1
Assessment Summary: EX 100%
Assessment Detail:
  • Exam (EX 100%)
Supplementary Assessment:
Like-for-like reassessment (where allowed by programme regulations)
Requisites: Before taking this module you must take CH20149 OR take CH20150
Learning Outcomes: After studying this unit students should be able to:
* Understand the factors that affect the structure, stability, and reactivity of radicals;
* Describe why radical chemistry is useful in synthesis;
* Explain the mechanisms of both chain and non-chain radical processes;
* Appreciate the catalysis modes that are relevant to radical-based reactions;
* Apply the information learned to solve unseen problems in radical chemistry selected from contemporary research literature.


Aims: The aim of the unit is to give students a thorough grounding in the fundamental reactivity of radicals, and the most important radical-mediated reactions in organic synthesis. It will also introduce modern catalysis concepts that are applicable to reactions proceeding via radical intermediates.

Skills: Problem solving (T, F, A)
Scientific writing (F, A), Independent working (F)
Group working (F)

Content: 1. Fundamentals of radical structure, stability, and reactivity.
2. Methods for radical generation.
3. Radical chain reactions (with and without Bu3SnH).
4. Additions of radicals to alkenes.
5. C-H bond functionalisations.
6. Redox reactions via radical intermediates.
7. HAT (hydrogen atom transfer) catalysis.
8. Redox catalysis with transition metals.
9. Photoredox catalysis.
10. Mergers of different catalysis strategies.

Course availability:

CH40206 is Compulsory on the following courses:

Department of Chemistry
  • USCH-AAM03 : MChem(Hons) Chemistry with Study year abroad (Year 4)
  • USCH-AFM05 : MChem(Hons) Chemistry for Drug Discovery (Year 4)
  • USCH-AAM06 : MChem(Hons) Chemistry for Drug Discovery with Study year abroad (Year 4)
  • USCH-AKM03 : MChem(Hons) Chemistry for Drug Discovery with Industrial Placement (Year 4)
  • USCH-AKM02 : MChem(Hons) Chemistry with Industrial Placement (Year 4)

CH40206 is Optional on the following courses:

Department of Chemistry
  • USCH-AFM02 : MChem(Hons) Chemistry (Year 4)
  • USCH-AFM07 : MSci(Hons) Chemistry with Management (Year 4)
  • USCH-AKM07 : MSci(Hons) Chemistry with Management with Industrial Placement (Year 5)
  • USSC-AFM01 : MSci(Hons) Natural Sciences (Biochemistry with Chemistry stream) (Year 4)
  • USSC-AAM01 : MSci(Hons) Natural Sciences (Biochemistry with Chemistry stream) with Study year abroad (Year 5)
  • USSC-AKM01 : MSci(Hons) Natural Sciences (Biochemistry with Chemistry stream) with Professional Placement (Year 5)
  • USSC-AFM01 : MSci(Hons) Natural Sciences (Biochemistry with Pharmacology stream) (Year 4)
  • USSC-AAM01 : MSci(Hons) Natural Sciences (Biochemistry with Pharmacology stream) with Study year abroad (Year 5)
  • USSC-AKM01 : MSci(Hons) Natural Sciences (Biochemistry with Pharmacology stream) with Professional Placement (Year 5)
  • USSC-AFM01 : MSci(Hons) Natural Sciences (Biology with Chemistry stream) (Year 4)
  • USSC-AAM01 : MSci(Hons) Natural Sciences (Biology with Chemistry stream) with Study year abroad (Year 5)
  • USSC-AKM01 : MSci(Hons) Natural Sciences (Biology with Chemistry stream) with Professional Placement (Year 5)
  • USSC-AFM01 : MSci(Hons) Natural Sciences (Chemistry with Biochemistry stream) (Year 4)
  • USSC-AAM01 : MSci(Hons) Natural Sciences (Chemistry with Biochemistry stream) with Study year abroad (Year 5)
  • USSC-AKM01 : MSci(Hons) Natural Sciences (Chemistry with Biochemistry stream) with Professional Placement (Year 5)
  • USSC-AFM01 : MSci(Hons) Natural Sciences (Chemistry with Biology stream) (Year 4)
  • USSC-AAM01 : MSci(Hons) Natural Sciences (Chemistry with Biology stream) with Study year abroad (Year 5)
  • USSC-AKM01 : MSci(Hons) Natural Sciences (Chemistry with Biology stream) with Professional Placement (Year 5)
  • USSC-AFM01 : MSci(Hons) Natural Sciences (Chemistry with Pharmacology stream) (Year 4)
  • USSC-AAM01 : MSci(Hons) Natural Sciences (Chemistry with Pharmacology stream) with Study year abroad (Year 5)
  • USSC-AKM01 : MSci(Hons) Natural Sciences (Chemistry with Pharmacology stream) with Professional Placement (Year 5)
  • USSC-AFM01 : MSci(Hons) Natural Sciences (Chemistry with Physics stream) (Year 4)
  • USSC-AAM01 : MSci(Hons) Natural Sciences (Chemistry with Physics stream) with Study year abroad (Year 5)
  • USSC-AKM01 : MSci(Hons) Natural Sciences (Chemistry with Physics stream) with Professional Placement (Year 5)
  • USSC-AFM01 : MSci(Hons) Natural Sciences (Physics with Chemistry stream) (Year 4)
  • USSC-AAM01 : MSci(Hons) Natural Sciences (Physics with Chemistry stream) with Study year abroad (Year 5)
  • USSC-AKM01 : MSci(Hons) Natural Sciences (Physics with Chemistry stream) with Professional Placement (Year 5)

Notes:

  • This unit catalogue is applicable for the 2023/24 academic year only. Students continuing their studies into 2024/25 and beyond should not assume that this unit will be available in future years in the format displayed here for 2023/24.
  • Courses and units are subject to change in accordance with normal University procedures.
  • Availability of units will be subject to constraints such as staff availability, minimum and maximum group sizes, and timetabling factors as well as a student's ability to meet any pre-requisite rules.
  • Find out more about these and other important University terms and conditions here.