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Mass Spectrometry

Find out about the Mass Spectrometry service.


A Mass Spectrometer
Mass Spectrometry is a key technique in identifying unknowns.

Mass Spectrometry is a sensitive technique used to identify and quantify compounds based on their mass, charge, structure and elemental composition. It has many applications including:

  • Organic and inorganic synthesis product confirmation
  • Protein identification
  • Impurity profiling
  • Identification of unknowns
  • Reaction monitoring
  • Environmental screening

Application notes

Learn how to routinely quantitate amino acids, with additional untargeted analysis capabilities, using mass spectrometry.

Read on to learn how TD-GC-MS can be used for the detection of volatile compounds.

Read this quick introduction to what MALDI-TOF-MS can do and how it works.

Our equipment

  • Automated Agilent QTOF (Walkup) used with HPLC (4 chromatography columns) for routine small molecule, peptide and intact protein analysis.

  • Agilent GC-MSD equipped with Thermal Desorption for volatile and semi-volatile organic compound (VOC, sVOC) gas chromatographic analysis.

  • Bruker MaXis HD ESI-QTOF mass spectrometer for high mass accuracy, coupled to a Thermo Scientific Dionex Ultra High Performance Liquid Chromatography (UPLC) unit.

  • Bruker AutoFlex Matrix-Assisted Laser Desorption Ionisation (MALDI) mass spectrometer for polymer and peptide analysis.

  • Bruker MicrOTOF Quadrupole Time-Of-Flight (ESI-QTOF) coupled to a syringe driver within a glove box, for air- and moisture-sensitive samples (part of the DReaM Facility).

  • Hiden HPR20 headspace mass spectrometer, detecting species from 1 - 300 AMU (part of the DReaM Facility).

We are also equipped with a stand-alone UPLC coupled to a UV detector (Dionex Thermo Scientific 3000 RS) for routine UV-purity determinations, including chiral separation of molecules, dependant on column availability.

Internal users

Please see our Moodle page.

Mass Spectrometry lab tour

Take a 360° tour of our Mass Spectrometry lab.


If you have any questions, please contact us.

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