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Research Associate (Fixed Term up to 1 year)

Pharmacy & Pharmacology

Salary:  Starting from £32,548, rising to £38,833 Pro rata for part year
Placed On:  Thursday 18 January 2018
Closing Date:  Sunday 18 February 2018
Interview Date:  Tuesday 24 April 2018
Reference:  AP5539

Spectroscopic imaging to assess drug pharmacokinetics in the skin

A postdoctoral research associate (PDRA) position is available for up to 1 year.

The central hypothesis of the research is that Raman spectroscopic imaging can provide a minimally invasive, accurate, sensitive, reproducible and at least semi-quantitative determination of the rate and extent to which a topically administered drug becomes available at its site of action in the skin (and, specifically, the epidermis).  The principal goal is to develop experimental methods to test this hypothesis ex vivo.  The project combines existing know-how in the assessment of topical bioavailability with a novel spectroscopic imaging strategy to explore whether the routine, facile and noninvasive measurement of drug pharmacokinetics in the skin is an attainable objective with potential for application in regulatory science and decision-making.

The specific responsibilities of the PDRA include:

1.  Obtaining unambiguous Raman spectroscopic analysis of a drug in the skin that avoids significant, background signal interference.

2.  Correcting for Raman signal attenuation of the drug as a function of increasing depth of measurement in the skin

3.  Using Raman imaging to (semi-) quantitatively measure a drug’s “input kinetics” into the epidermis.

4.  Validation of Raman imaging to quantify drug input kinetics into the epidermis.

5.  Using coherent Raman scattering and laser scanning confocal microscopies to track formulation constituents post-application to the skin.

6.  Data processing, analysis and interpretation.

The appointee to the position should have an established experience in biological and biophysical applications of Raman spectroscopy and familiarity with the pharmaceutical sciences underpinning drug delivery to the skin and other tissues.  The PDRA will perform a significant portion of the research with collaborators at the National Physical Laboratory (Teddington, U.K.). 

All enquiries should be addressed to Prof. Richard H. Guy (r.h.guy@bath.ac.uk), University of Bath, Department of Pharmacy & Pharmacology, Claverton Down, Bath, BA2 7AY, U.K.

Applications should include a full CV, list of publications/presentations and two letters of reference.

Interviews will be held week commencing 26th February.

 

The closing date for this job opportunity has now passed, and applications are no longer being accepted for this position

Further details:
The University of Bath is an equal opportunities employer and has an excellent international reputation with staff from over 60 different nations. To achieve our global aspirations, we welcome applicants from all backgrounds.