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University of Bath

Towards novel biosensor devices for improved cancer diagnosis

We are developing low-cost biosensors for robust cancer diagnostic sensors using a capacitance method with DNA aptamers.

We are collaborating with UNESP to develop low-cost capacitance biosensors using DNA aptamers for robust medical sensors. We will explore a new approach in electrochemical sensor design to take advantage of the developments made by the applicants. We will build on research carried out by Dr Bueno that uses sensing layers comprising recognition elements embedded within redox-active, self-assembled monolayers. It will also draw on Dr Estrela's research developing biosensors using synthetic recognition elements such as DNA aptamers.

The resultant sensing layers will be able to measure the binding of specific analytes. It will do this via a direct mechanism that is less dependent on the experimental conditions under which the sensors operate. We will prove how we can translate this technology into a novel approach to rapidly detect disease biomarkers.

Using technology developed by Dr Moschou, we will translate the sensors on to low-cost printed circuit boards (PCBs). This will allow us to fully integrate the sensors on to a portable device.

Our project will assess the use of this sensing strategy for model analytes and synthetic recognition elements. It will provide a baseline technology that can be adapted for other sensing elements and analytes as appropriate.