| Description:
| Aims:
To provide an understanding of how the molecular properties of biologically active molecules can be exploited for the development of biologically-derived products, novel tissue constructs, reactor systems, analytical devices and drug delivery devices.
Learning Outcomes:
Students should be able to demonstrate an understanding of the concepts and theories relating to the biospecific molecular interactions that can occur in biochemical systems. They should be able to derive the key isotherm equations used to describe ligand-receptor interactions and relate these to kinetic expressions for biological activity. They should be aware of how biological components can be incorporated into composite devices developed for analytical and drug release applications and how models describing the fundamental interactions can be used in the design of such systems. They should appreciate the significance of biological signalling mechanisms in cell and tissue engineering and understand the role of key cell adhesion molecules.
Skills:
Analysis and problem solving (taught/facilitated and assessed).
Content:
Introduction to lectins, antibodies and cell adhesion molecules (CAMs). Derivation of ligand receptor binding expressions, development of kinetic models for multi-substrate and reversible enzyme catalysed reactions. Methods of protein immobilisation and effects on intrinsic and kinetic properties. Use of enzymes in analytical devices and the significance of mass transfer limitations. Development of dilution assays based on antibodies and enzymes (ELISA). Role of CAMs in cell-matrix interactions and their importance in the design and synthesis of scaffold materials for tissue engineering applications. Cell signalling pathways. Development of responsive hydrogels for use in "intelligent" drug delivery systems. |
Credits: