This unit is the equivalent of BB10004 for students not in the department of Biology.
Aims & Learning Objectives:
Aims: To introduce the central pathways of fatty acid metabolism and mitochondrial oxidation and integrate these into overall cell function. To inculcate appreciation of the metabolic pathways into function at the organ and tissue level. To teach the implications of stereochemistry into the biochemistry of key metabolic intermediates.
After taking this course the student should be able to:
* appreciate the principles of mitochondrial oxidative function
* understand lipid structure and the pathways of fatty acid oxidation
and synthesis
* understand the mechanisms of neurotransmission and muscle contraction
* comprehend the stereochemistry of small organic molecules of
biological importance
Content:
The course is a direct follow on from BB10120. Topics studied are 1) mitochondrial bioenergetics, respiration, oxidative phosphorylation and the chemiosmotic theory; 2) lipid metabolism structure of lipids, catabolism and anabolism of fatty acids, ketogenesis and coordination with other metabolic pathways; 3) biochemistry of animal tissues and organs, such as mechanisms of neurotransmission and muscle contraction; 4) stereochemistry of simple carbohydrates and citric acid cycle intermediates with applications of biochemical mechanisms.
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