Aims & Learning Objectives:
Aims: To provide an in-depth understanding of the relationship between DNA synthesis, damage & repair mechanisms in relation to cell cycle and apoptosis. Also provides an understanding of how disruption of normal cellular function leads to disease processes, especially cancer. After taking this course the student should be able to:
* give a detailed account of DNA replication, damage and repair in prokaryotic (bacterial / viral) and eukaryotic systems;
* understand the cross talk between cell cycle and apoptosis in relation to oncogenesis;
* understand the rationale behind cancer therapy, either conventional approaches of radio/chemotherapy or newer approaches of genetherapy, immunotherapy, angiotherapy etc.
Content:
DNA replication and repair in relation to disease. Role of cell cycle and apoptosis in oncogenesis. Various modes of cancer therapy.
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