Aims & Learning Objectives:
Aims: To introduce principles of microbial pathogenicity (of humans), with particular regard to the roles of the cell envelope and bacterial toxins. To present detailed aspects of the physiological and biochemical processes involved.
After taking this course the student should be able to:
* have a sound understanding of a range of physiological properties and biochemical mechanisms, particularly in relation to bacterial pathogenicity towards humans
Content:
Introduction to microbial pathogenicity; iron transport and the bacterial cell membrane; the mechanisms of cell adhesion; bacterial biofilms - their nature, formation and involvement in health problems; an introduction to bacterial toxins and their role in disease; structural properties and detection of toxins; cell envelope structural components and their role in vaccine development; E. coli H0157, an important 'new' pathogen; AIDS.
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