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Department of Biology & Biochemistry, Unit Catalogue 2007/08


BB40109 Structural biology in biotechnology & medicine

Credits: 6
Level: Masters
Semester: 2
Assessment: CW 100%
Requisites:
Before taking this unit you must take BB30046
Or you must have taken suitable degree units from another University.
Aims & Learning Objectives:
Aims: to use our current knowledge of biomolecules to explore their applications in Biotechnology and Medicine, with particular emphasis on Structural Biology techniques. After taking this course the student should be able to:
* Describe a wide range of examples of biotechnological and medical uses.
* Understand the applications of state-of-the-art techniques in Structural Molecular Biology.
* Show development of presentation and discussion skills
Content:
Protein structures and interactions; protein-peptide, protein-receptor, antigen-antibody, protein-nucleic acid and protein-carbohydrate interactions. Nucleic acid interactions with small molecules. Large macromolecular assemblies. Protein-engineering. Structure-based drug design; high-throughput screening; structure-sctivity relationships by NMR. Enzyme catalysis. Structural genomics.