Aims & Learning Objectives:
To introduce and illustrate how advanced synthetic organic chemistry is used in the preparation of medicinally valuable compounds.
After studying this unit, students should be able to:
* Describe several methods for preparing compound libraries based on a given framework.
* Apply the concept of Solid Phase Organic Synthesis (SPOS) to combinatorial chemistry.
* Define reagents and strategies for the assembly of defined stereochemical arrays.
* Design rational analogues, or modified compounds from given medical agents.
Content:
The unit will illustrate the complex relationship between organic chemistry and medicine:
Introduction to combinatorial chemistry. Solid Phase Organic Synthesis (SPOS), resins and linkers. Parallel synthesis. Case studies. In addition, several disease areas will be selected and compounds used to treat them considered. The focus of the unit will be the methods used to synthesise those compounds. Areas covered will include:- Prostaglandins, b-Lactams, ionophoro antibiotics and anti-cancer drugs.
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