Department of Chemistry, Unit Catalogue 2007/08 |
CH40037 Synthesis of medicinal compounds |
| Credits: 3 |
| Level: Masters |
| Semester: 2 |
| Assessment: EX100 |
| Requisites: |
| Before taking this unit you must take CH20014 and in taking this unit you cannot take CH30037 |
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Aims & Learning Objectives: To introduce and illustrate how advanced synthetic organic chemistry is used in the preparation of medicinally valuable compounds with an emphasis on synthetic planning and execution. After studying this Unitm students should be able to: * Describe several methods for preparing compound libraries based on a given framework. * Apply the concept of Solid Phase Organic Synthesis (SPOS) to combinatorial chemistry. * Define reagents and strategies for the assembly of defined stereochemical arrays. * Design rational analogues, or modified compounds from given medicinal agents. * Analyse and use reterosynthetic methods to plan synthetic routes to a range of complex target molecules. Content: The unit will illustrate the complex relationship between organic chemistry and medicine: Introduction to combinatorial chemistry. Solid Phase Organic Synthesis (SPOS), resins and linkers. Parallel synthesis. Case studies. In addition, several disease areas will be selected and compounds used to treat them considered. The focus of the unit will be the methods used to synthesise those compounds and in particular the synthetic strategies employed. Areas covered will include:- Prostaglandins, b-Lactams, ionophoro antibiotics and anti-cancer drugs. |