Department of Pharmacy and Pharmacology

Giordano Pula

Lecturer

7 West 3.10

Email: g.pula@bath.ac.uk

Tel: +44 (0) 1225 38 6428

 

Dr Giordano Pula

Profile

Research

  1. Vascular Biology: Paracrine Regulation of Endothelial Cell Motility and Angiogenesis, Regenerative Angiogenesis, Redox Regulation of Cell Physiology and Angiogenic Responses, Endothelial Progenitor Cell Biology.
  2. Thrombosis and Haemostasis: Autocrine and Paracrine Regulation of Platelet Activity, Redox Regulation of Platelet Responses and Thrombus Formation, Platelet Intracellular Signaling and Protein Kinase Cascades, Integrin regulation.

Current funding

  1. BBSRC ALERT14 (2014). Co-applicant. Title: A Facility for Advanced Imaging and Analysis under Hypoxic Conditions for Bath Scientists and GW4 partners (BB/M012409/1).
  2. Alzheimer Research UK (2013). Main applicant. Title: Analysis of the role of platelet-derived amyloid Aβ peptides in vascular inflammation and thrombotic complications of Alzheimer disease (ARUK-PPG2013B-8).
  3. Royal Society Project Grant (2012). Main applicant. Title: Characterisation of endothelial colony-forming cell (ECFC) precursors in human peripheral blood by fluorescence-assisted cell sorting (FACS). (RG120494).
  4. Wellcome Trust, Multiuser Equipment Grant (2012). Cell Sorting Flow Cytometry for the Study of Live Cell, Cell Surface and Intracellular Processes, (ZR-W0258A).
  5. University of Bath Research Studentship (2012). Endothelial progenitor cells and biomaterials: a powerful synergy for innovative regenerative medicine.
  6. BBSRC Project Grant (2012). Paracrine regulation of endothelial cell motility and angiogenesis by deoxyribose-1-phosphate. (BB/J002690/1).

Publications

Fortunato, T., De Bank, P. and Pula, G., 2017. Vascular Regenerative Surgery: Promised Land for Tissue Engineers? International Journal of Stem Cell Research and Transplantation, 5 (2), pp. 268-276.

Bhalla, N., Di Lorenzo, M., Estrela, P. and Pula, G., 2017. Semiconductor technology in protein kinase research and drug discovery:sensing a revolution. Drug Discovery Today, 22 (2), pp. 204-209.

Canobbio, I., Visconte, C., Oliviero, B., Guidetti, G., Zara, M., Pula, G. and Torti, M., 2016. Increased platelet adhesion and thrombus formation in a mouse model of Alzheimer's disease. Cellular Signalling, 28 (12), pp. 1863-1871.

Metcalfe, C., Ramasubramoni, A., Pula, G., Harper, M. T., Mundell, S. J. and Coxon, C. H., 2016. Thioredoxin inhibitors attenuate platelet function and thrombus formation. PLoS ONE, 11 (10), e0163006.

Fortunato, T., Beltrami, C., Emanueli, C., De Bank, P. and Pula, G., 2016. Platelet lysate gel and endothelial progenitors stimulate microvascular network formation in vitro: tissue engineering implications. Scientific Reports, 6, 25326.

Posner, M. G., Upadhyay, A., Alsheikh Abubaker, A., Fortunato, T. M., Vara, D., Canobbio, I., Bagby, S. and Pula, G., 2016. Extracellular fibrinogen-binding protein (Efb) from Staphylococcus aureus inhibits the formation of platelet-leukocyte complexes. Journal of Biological Chemistry, 291 (6), pp. 2764-2776.

Pula, G., Posner, M., Upadhyay, A., Vara, D. and Bagby, S., 2016. Extracellular fibrinogen binding protein (Efb) from S. aureus inhibits the formation of platelet/leukocyte complexes. In: Platelet Symposium, 2016-09-12 - 2016-09-16.

Bhalla, N., Formisano, N., Miodek, A., Jain, A., Di Lorenzo, M., Pula, G. and Estrela, P., 2015. Plasmonic ruler on field-effect devices for kinase drug discovery applications. Biosensors and Bioelectronics, 71, pp. 121-128.

Fortunato, T., De Bank, P. and Pula, G., 2015. Platelet Lysate Gel and Endothelial Progenitors Stimulate Microvascular Network Formation In Vitro: Implications for Regenerative Medicine. In: 3rd SW Regional Regenerative Medicine Meeting, 2015-09-22 - 2015-09-22, DOuble Tree Hilton.

Formisano, N., Bhalla, N., Wong, L. C. C., Di Lorenzo, M., Pula, G. and Estrela, P., 2015. Multimodal electrochemical and nanoplasmonic biosensors using ferrocene crowned nanoparticles for kinase drug discovery applications. Electrochemistry Communications, 57, pp. 70-73.

Fortunato, T., De Bank, P. and Pula, G., 2015. Human Platelet Lysate Gel as a Substrate for Isolation and Delivery of Endothelial Colony-Forming Cells. In: Joint 28th European Society for Microcirculation (ESM) 8th European Vascular Biology Organisation (EVBO) Meeting, 2015-06-03 - 2015-06-06.

Pula, G., Fortunato, T. and De Bank, P., 2015. Human platelet lysate gel (HPLG) supports and stimulates endothelial progenitor cell-driven vasculogenesis. In: XXV Congress of the International Society on Thrombosis and Haemostasis, 2015-06-20 - 2015-06-25.

Pula, G., Estrela, P., Bhalla, N. and Di Lorenzo, M., 2015. Platform for Change. [Non-academic press]

Estrela, P., Bhalla, N., Di Lorenzo, M. and Pula, G., 2015. Researchers develop platform to aid kinase drug discovery. [Non-academic press]

Bhalla, N., Di Lorenzo, M., Pula, G. and Estrela, P., 2015. Protein phosphorylation detection using dual-mode field-effect devices and nanoplasmonic sensors. Scientific Reports, 5, 8687.

Canobbio, I., Abubaker, A. A., Visconte, C., Torti, M. and Pula, G., 2015. Role of amyloid peptides in vascular dysfunction and platelet dysregulation in Alzheimer’s disease. Frontiers in Cellular Neuroscience, 9 (65).

Bhalla, N., Pathak, S., Bowen, C., Taylor, J., Di Lorenzo, M., Pula, G. and Estrela, P., 2015. Field-effect devices for kinase drug discovery. In: 4th International Conference on Bio-Sensing Technology, 2015-05-10 - 2015-05-13.

Pula, G., Fortunato, T. and De Bank, P., 2015. Human platelet lysate gel (HPLG) supports and stimulates endothelial progenitor cell-driven vasculogenesis. Journal of Thrombosis and Haemostasis, 13 (S2), p. 271.

Bhalla, N., Formisano, N., Miodek, A., Di Lorenzo, M., Pula, G. and Estrela, P., 2015. Integrated nanoplasmonic and field-effect devices for kinase drug discovery. In: 2nd International Conference on Label-Free Technologies, 2015-03-12 - 2015-03-14.

Bhalla, N., Formisano, N., Miodek, A., Di Lorenzo, M., Pula, G. and Estrela, P., 2015. Integrated nanoplasmonic and field-effect sensing for kinase drug discovery applications. In: 2nd International Conference on Label-Free Technologies, 2015-03-12 - 2015-03-14.

Pula, G., Posner, M., Upadhyay, A. and Bagby, S., 2015. The extracellular fibrinogen-binding protein (Efb) secreted by Staphylococcus aureus binds P-selectin and competitively inhibits its interaction with P-selectin glycoprotein ligand-1 (PSGL-1). In: International Society of Thrombosis and Haemostasis, 2015-06-09 - 2015-06-13.

Fortunato, T.M., Vara, D.S., Wheeler-Jones, C.P. and Pula, G., 2014. Expression of protease-activated receptor 1 and 2 and anti-tubulogenic activity of protease-activated receptor 1 in human endothelial colony-forming cells. PLoS ONE, 9 (10), e109375.

Canobbio, I., Guidetti, G.F., Oliviero, B., Manganaro, D., Vara, D., Torti, M. and Pula, G., 2014. Amyloid β-peptide-dependent activation of human platelets:Essential role for Ca2=+ and ADP in aggregation and thrombus formation. Biochemical Journal, 462 (3), pp. 513-523.

Bhalla, N., Di Lorenzo, M., Pula, G. and Estrela, P., 2014. Protein phosphorylation analysis based on proton release detection:potential tools for drug discovery. Biosensors and Bioelectronics, 54, pp. 109-114.

Bhalla, N., Di Lorenzo, M., Pula, G. and Estrela, P., 2014. Novel tools for protein phosphorylation analysis based on proton release detection. In: 24th Anniversary World Congress on Biosensors, 2014-05-27 - 2014-05-30.

Vara, D. and Pula, G., 2014. Reactive oxygen species:physiological roles in the regulation of vascular cells. Current Molecular Medicine, 14 (9), pp. 1103-25.

Pula, G., Posner, M., Upadhyay, A. and Bagby, S., 2013. Extracellular fibrinogen-binding protein (Efb) from Staphylococcus aureus inhibits fibrinogen binding, platelet aggregation and whole blood thrombus formation. In: 14th UK Platelet Group Meeting, 2013-09-11 - 2013-09-11, Austin Court.

Vara, D., Campanella, M. and Pula, G., 2013. The novel NOX inhibitor 2-acetylphenothiazine impairs collagen-dependent thrombus formation in a GPVI-dependent manner. British Journal of Pharmacology, 168 (1), pp. 212-224.

Vara, D. S., Campanella, M., Canobbio, I., Dunn, W. B., Pizzorno, G., Hirano, M. and Pula, G., 2013. Autocrine amplification of integrin αIIbβ3 activation and platelet adhesive responses by deoxyribose-1-phosphate. Thrombosis and Haemostasis, 109 (6), pp. 1108-1119.

Pula, G., Posner, M., Upadhyay, A. and Bagby, S., 2013. Extracellular fibrinogen-binding protein (Efb) from Staphylococcus aureus inhibits fibrinogen binding, platelet aggregation and whole blood thrombus formation. In: XXIVth Congress of the International Society on Thrombosis and Haemostasis, 2013-06-20 - 2013-06-24, Amsterdam RAI.

Pula, G., Garonna, E., Dunn, W. B., Hirano, M., Pizzorno, G., Campanella, M., Schwartz, E. L., El Kouni, M. H. and Wheeler-Jones, C. P. D., 2010. Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphate. Arteriosclerosis, thrombosis, and vascular biology, 30 (12), pp. 2631-2638.

Prokopi, M., Pula, G., Mayr, U., Devue, C., Gallagher, J., Xiao, Q., Boulanger, C. M., Westwood, N., Urbich, C., Willeit, J., Steiner, M., Breuss, J., Xu, Q., Kiechl, S. and Mayr, M., 2009. Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures. Blood, 114 (3), pp. 723-732.

Pula, G., Mayr, U., Evans, C., Prokopi, M., Vara, D. S., Yin, X., Astroulakis, Z., Xiao, Q., Hill, J., Xu, Q. and Mayr, M., 2009. Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures. Circulation Research, 104 (1), pp. 32-40.

Pula, G., Perera, S., Prokopi, M., Sidibe, A., Boulanger, C. M. and Mayr, M., 2008. Proteomic analysis of secretory proteins and vesicles in vascular research. Proteomics Clinical Applications, 2 (6), pp. 882-891.

Pula, G. and Poole, A. W., 2008. Critical roles for the actin cytoskeleton and cdc42 in regulating platelet integrinα2β1. Platelets, 19 (3), pp. 199-210.

Pula, G. and Krause, M., 2008. Role of Ena/VASP Proteins in Homeostasis and Disease. Handbook of experimental pharmacology, 186 (1), pp. 39-65.

This list was generated on Mon Oct 23 15:29:26 2017 IST.

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