This Commission identifies that three interconnected global threats, non-communicable diseases, infectious disease outbreaks, and environmental degradation, continue to worsen despite international commitments. These threats share underlying drivers rooted in political and economic systems that prioritise growth over health and sustainability, disproportionately harming people in low-income settings. To address this, authors examined the physical environment and transport, agriculture and food, and energy systems, developing ten objectives and evidence‑based recommendations through reviews, expert input, and economic modelling. Their findings highlight how intertwined factors, such as land clearing for palm oil, unhealthy diets, ecosystem destruction, and climate change, simultaneously fuel disease and environmental crises. The Commission emphasises that meaningful progress requires transforming the environments that shape population behaviour, rather than relying on individual choice, and calls for governments and businesses to take systemic action. Their priority recommendations focus on replacing harmful policies, strengthening institutions and civil society, and building capacity for integrated responses, with measurable progress needed by 2030.