Active projects range from developmental biology to tissue homeostasis and tissue repair during the life course of an organism. Disease areas investigated by our research teams include neurodegenerative disorders, cancer, infectious diseases, and diabetes.
To gain new insights in these areas we combine biochemical, molecular, genetic, epigenetic, imaging, ‘omics’ and bioinformatics approaches with 2D and 3D cell culture techniques and the use of model organisms such as zebrafish and mouse. Using cutting-edge technologies allows us to gain insight into the detailed function of a single molecule in a cell up to the physiology and pathology of an organ.
- Biotechnological approaches to cell manipulation
- Development, stem cells, and tissue repair
- Gene expression, epigenetics and RNA biology
- Infectious disease
- Mechanisms of ageing, growth regulation and cancer
- Neuronal wiring, network function and neurodegeneration
- Plant growth, development and stress responses
- Protein function, dysfunction and manipulation
- Systems biology and cell signalling