DReaM Facility equipment

Learn more about the equipment and instruments that are part of the Dynamic Reaction Monitoring Facility.

NMR Spectrometer

Nuclear Magnetic Resonance (NMR) spectroscopy is an analytical technique used to determine the structure of chemical moieties.


NMR spectrometer

The 500 MHz Bruker NMR spectrometer with a Prodigy cryoprobe is the centrepiece of the DReaM Facility. Using the InsightMR flowprobe and software, the homogeneous reaction mixture is pumped directly from the reaction vessel into the flow cell in the spectrometer, analysed in flow and then returned to the reaction vessel.

The Prodigy cryoprobe is able to observe nuclei with Larmor frequencies of 15N and above. Routinely, 1H, 19F, 31P and 13C experiments are used.

The spectrometer is able to maintain reaction temperatures between -20 and 80 °C.

Mass Spectrometers

Mass Spectrometry (MS) is an analytical technique used to determine the molecular weight of species present in the reaction mixture.


Mass spectrometer

The DReaM Facility hosts two mass spectrometers, one to study the liquid phase and one to study the gas phase, or headspace, of the reaction.

  • The liquid phase mass spectrometer is a Bruker MicroTOFQ. It can sample from the reaction mixture in the flow path as it returns to the reaction vessel.

  • The gas phase mass spectrometer is a Hiden HPR20. This instrument samples directly from the headspace of the reaction vessel. It can detect species from 1 - 300 AMU. For standalone applications it can be used for up to 30 bar pressure, but the remainder of the flow equipment is only rated to 10 bar.

Other analytical techniques

The DReaM Facility is also home to a UV/Vis spectrometer, a polarimeter and a HPLC (High Performance Liquid Chromatography).


UV spectrometer, pump and HPLC valve

The Ocean Optics UV/Vis spectrometer and the polarimeter have flow cells within the flow pathway, so the reaction mixture can be passed though for analysis, after passing through the NMR flow cell.

Samples are taken from the reaction mixture in the flow pathway for chiral HPLC analysis, on our Agilent 1260 series HPLC, using a method developed by the user in advance. Where samples are not suitable for HPLC analysis directly from the reaction mixture, it is also be an option to manually take samples from the reaction mixture for work up prior to injection into the HPLC.

Explore DReaM

Have a look around the DReaM laboratory, which is also home to two of the other NMR spectrometers within MC².


Read our guidelines for use of the DReaM Facility before applying

Download guidelines A call for proposals is open now and will close on 8 February 2019