Successful drug discovery depends not only on identifying promising therapeutic molecules, but also on understanding how they work in complex biological systems. Our researchers use chemical biology, systems biology and advanced disease models to investigate protein function, signalling pathways and cellular networks that underpin health and disease.

Discovering therapeutic opportunities

Using chemical probes, quantitative proteomics, human organoids, zebrafish and alternative non-mammalian disease models, we investigate target engagement, mechanism of action and biological responses in physiologically relevant systems. These complementary approaches reveal therapeutic opportunities while providing fundamental insight into disease mechanisms.

By linking molecular mechanism with biological function, we explain how therapeutic interventions reshape cellular and organismal biology, providing the foundation for more effective medicines and new therapeutic opportunities.