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CH40068: Physical organic chemistry

Follow this link for further information on academic years Academic Year: 2015/6
Further information on owning departmentsOwning Department/School: Department of Chemistry
Further information on credits Credits: 3
Further information on unit levels Level: Masters UG & PG (FHEQ level 7)
Further information on teaching periods Period: Semester 2
Further information on unit assessment Assessment Summary: EX 100%
Further information on unit assessment Assessment Detail:
  • Examination (EX 100%)
Further information on supplementary assessment Supplementary Assessment: Like-for-like reassessment (where allowed by programme regulations)
Further information on requisites Requisites: Before taking this module you must take CH20149 OR take CH20150
In taking this module you cannot take CH30068
Further information on descriptions Description: Aims:
To revise some basic concepts in physical organic chemistry and develop a number of ideas used to correlate reactivity and mechanism in a range of organic reactions.

Learning Outcomes:
After studying the Unit, students should be able to:
* Describe some experimental tools for investigating reaction mechanisms and the use of some theoretical models for their correlation and interpretation
* Suggest solutions for complex problems involving combinations of numerical and mechanistic information from a variety of sources.
* Propose appropriate experimental approaches for determination of organic reaction mechanisms.

Skills:
Problem solving (T, F, A), Scientific writing (F, A), Independent working (F).

Content:
Energy changes in equilibria and reactivity. Transition states and saddle points. Activation parameters. Analysis of reaction coordinates. Principle of Least Nuclear Motion. Hammond Postulate. More O┬┐Ferrall - Jencks diagrams. Rate - equilibrium correlations. Hammett equation as an example of a linear free-energy relationship. Significance of s and rfor reactivity and mechanism. Complex Hammett plots: change in mechanism vs. change in rate-determining step. Equilibrium and kinetic isotope effects. Primary and secondary effects and their significance. Heavy-atom effects. Solvent isotope effects.
Further information on programme availabilityProgramme availability:

CH40068 is Optional on the following programmes:

Department of Chemistry
  • USCH-AAM03 : MChem(Hons) Chemistry with Study year abroad (Year 4)
  • USCH-AAM06 : MChem(Hons) Chemistry for Drug Discovery with Study year abroad (Year 4)
  • USCH-AKM03 : MChem(Hons) Chemistry for Drug Discovery with Industrial Placement (Year 4)
  • USCH-AKM02 : MChem(Hons) Chemistry with Industrial Placement (Year 4)
  • USCH-AFM07 : MSci(Hons) Chemistry with Management (Year 4)
  • USCH-AKM07 : MSci(Hons) Chemistry with Management with Industrial Placement (Year 5)
  • RSCH-AFM03 : Integrated PhD in Chemistry
  • TSCH-AFM01 : MRes Chemistry
  • TSCH-AFM04 : MSc Chemistry for Drug Discovery
Programmes in Natural Sciences
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Year 4)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences with Professional Placement (Year 5)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences with Study year abroad (Year 5)

Notes:
* This unit catalogue is applicable for the 2015/16 academic year only. Students continuing their studies into 2016/17 and beyond should not assume that this unit will be available in future years in the format displayed here for 2015/16.
* Programmes and units are subject to change at any time, in accordance with normal University procedures.
* Availability of units will be subject to constraints such as staff availability, minimum and maximum group sizes, and timetabling factors as well as a student's ability to meet any pre-requisite rules.