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CH40128: Topics in organic chemistry

Follow this link for further information on academic years Academic Year: 2012/3
Follow this link for further information on owning departmentsOwning Department/School: Department of Chemistry
Follow this link for further information on credits Credits: 6
Follow this link for further information on unit levels Level: Masters UG & PG (FHEQ level 7)
Follow this link for further information on period slots Period: Semester 1
Follow this link for further information on unit assessment Assessment: EX 100%
Follow this link for further information on supplementary assessment Supplementary Assessment: Like-for-like reassessment (where allowed by programme regulations)
Follow this link for further information on unit rules Requisites: Before taking this unit you must take CH20014 and take CH20078 or suitable courses from another university. In taking this unit you cannot take Stereoselective Organic Synthesis as a component of CH30061.
Follow this link for further information on unit content Description: Aims:
The aim of the unit is to give students a thorough grounding in the methods, strategies and reagents employed in modern stereoselective organic synthesis.

Learning Outcomes:
After studying this unit students should be able to:
* Analyse the stereochemical course of a variety of reactions.
* Describe reagent systems to effect a wide range of simple transformation.
* Appreciate why organoelement chemistry is used in synthesis.
* Describe a wide range of new synthetic transformations.
* Describe fully the mechanism of these reactions.
* Apply the information learnt to solve problems.
* Critically evaluate publications from the recent literature to illustrate the course themes.
* Demonstrate knowledge of selected recent developments in organic chemistry.

Problem solving (T, F, A), Scientific writing (F, A), Independent working (F), Group working (F).

The unit begins with a section concerned with the simple diastereoselection, focusing on the reactions of carbonyl and alkene systems. The concepts of allylic strain and directed reactions are introduced. The use of chiral auxiliaries to control the sterochemistry of organic reactions forms the second section. Particular systems studied include the use of SAMP and RAMP hydrozones and Evans' auxiliaries to control a range of chiral-enolate based bond constructions. The final section of the unit focuses on the development and application of practical enantioselective catalysts of particular relevance to the fine chemical industry. Examplse of transformations to be studied will include hydrogenation of double bonds, oxidations and carbon-carbon bond forming reactions. Organoboron chemistry. Organosilicon chemistry. Organophosphorus chemistry. Organosulphur chemistry. Organometallics in Organic synthesis. Carbonylation reactions. Coupling Reactions. Methods of C-C bond formation.
Follow this link for further information on programme availabilityProgramme availability:

CH40128 is Optional on the following programmes:

Programmes in Natural Sciences
  • UXXX-AFM01 : MSci (hons) Natural Sciences (Full-time) - Year 4
  • UXXX-AKM02 : MSci (hons) Natural Sciences with Professional Placement (Full-time with Thick Sandwich Placement) - Year 5
  • UXXX-AAM02 : MSci (hons) Natural Sciences with Study Year Abroad (Full-time with Study Year Abroad) - Year 5

* This unit catalogue is applicable for the 2012/13 academic year only. Students continuing their studies into 2013/14 and beyond should not assume that this unit will be available in future years in the format displayed here for 2012/13.
* Programmes and units are subject to change at any time, in accordance with normal University procedures.
* Availability of units will be subject to constraints such as staff availability, minimum and maximum group sizes, and timetabling factors as well as a student's ability to meet any pre-requisite rules.