|
 Academic Year:
| 2012/3 |
| Owning Department/School:
| Department of Chemistry |
| Credits:
| 3 |
| Level:
| Masters UG & PG (FHEQ level 7) |
| Period: |
Semester 1 |
| Assessment:
| EX100 |
| Supplementary Assessment: |
Like-for-like reassessment (where allowed by programme regulations) |
| Requisites:
| Before taking this unit you must take CH20149 or take CH20150 and in taking this unit you may not take 'Recent developments in organic chemistry' as a component of CH30061. |
| Description:
| Aims: The aim of the unit is to give students a thorough grounding in the methods, strategies and reagents employed in modern stereoselective organic synthesis. Learning Outcomes: After studying this unit students should be able to: * Analyse the stereochemical course of a variety of reactions * Describe reagent systems to effect a wide range of simple transformation * Describe fully the mechanism of these reactions. Apply the information learnt to solve problems * Critically evaluate publications from the recent literature * Use examples of recent developments in modern stereoselective organic synthesis. Skills: Problem solving (T, F, A) Scientific writing (F, A), Independent working (f) Group working (F). Content: The unit begins with a section concerned with simple diastereoselection, focusing on the reactions of carbonyl and alkene systems. The concepts of allylic strain and directed reactions are introduced. The use of chiral auxiliaries to control the stereochemistry of organic reactions forms the second section. Particular systems studied include the use of SAMP and RAMP hydrazones and Evans' auxiliaries to control a range of chiral-enolate based bond constructions. |
| Programme availability: |
CH40216 is Optional on the following programmes:Programmes in Natural Sciences
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