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CH40068: Physical organic chemistry

Follow this link for further information on academic years Academic Year: 2013/4
Further information on owning departmentsOwning Department/School: Department of Chemistry
Further information on credits Credits: 3
Further information on unit levels Level: Masters UG & PG (FHEQ level 7)
Further information on teaching periods Period: Semester 2
Further information on unit assessment Assessment: EX 100%
Further information on supplementary assessment Supplementary Assessment: Like-for-like reassessment (where allowed by programme regulations)
Further information on requisites Requisites: Before taking this unit you must take CH20149 or take CH20150 and in taking this unit you cannot take CH30068
Further information on descriptions Description: Aims & Learning Objectives:
To revise some basic concepts in physical organic chemistry and develop a number of ideas used to correlate reactivity and mechanism in a range of organic reactions. After studying the Unit, students should be able to:
* Describe some experimental tools for investigating reaction mechanisms and the use of some theoretical models for their correlations and interpretation.
* Suggest solutions for complex problems involving combinations of numerical and mechanistic information from a variety of sources.
* Propose appropriate experimental approaches for determination of organic reaction mechanisms.

Energy changes in equilibria and reactivity. Transition states and saddle points. Activation parameters. Analysis of reaction coordinates. Principle of Least Nuclear Motion. Hammond Postulate. More O'Ferrall - Jencks diagrams. Rate - equilibrium correlations. Hammett equation as an example of a linear free-energy relationship. Significance of s and r for reactivity and mechanism. Complex Hammett plots: change in mechanism vs. change in rate-determining step. Equilibrium and kinetic isotope effects. Primary and secondary effects and their significance. Heavy-atom effects. Solvent isotope effects.
Further information on programme availabilityProgramme availability:

CH40068 is Optional on the following programmes:

Department of Chemistry
  • RSCH-AFM03 : Integrated PhD Chemistry (Full-time) - Year 1
  • USCH-AKM03 : MChem (hons) Chemistry for Drug Discovery with Industrial Training (Full-time with Thick Sandwich Placement) - Year 4
  • USCH-AAM06 : MChem (hons) Chemistry for Drug Discovery with Study Year Abroad (Full-time with Study Year Abroad) - Year 4
  • USCH-AKM02 : MChem (hons) Chemistry with Industrial Training (Full-time with Thick Sandwich Placement) - Year 4
  • USCH-AAM03 : MChem (hons) Chemistry with Study Year Abroad (Full-time with Study Year Abroad) - Year 4
  • TSCH-AFM01 : MRes Chemistry (Full-time) - Year 1
  • TSCH-AFM04 : MSc Chemistry for Drug Discovery (Full-time) - Year 1
  • USCH-AFM07 : MSci (hons) Chemistry with Management (Full-time) - Year 4
  • USCH-AKM07 : MSci (hons) Chemistry with Management with Industrial Training (Full-time with Thick Sandwich Placement) - Year 5
Programmes in Natural Sciences
  • UXXX-AFM01 : MSci (hons) Natural Sciences (Full-time) - Year 4
  • UXXX-AKM02 : MSci (hons) Natural Sciences with Professional Placement (Full-time with Thick Sandwich Placement) - Year 5
  • UXXX-AAM02 : MSci (hons) Natural Sciences with Study Year Abroad (Full-time with Study Year Abroad) - Year 5

* This unit catalogue is applicable for the 2013/4 academic year only. Students continuing their studies into 2014/15 and beyond should not assume that this unit will be available in future years in the format displayed here for 2013/14.
* Programmes and units are subject to change at any time, in accordance with normal University procedures.
* Availability of units will be subject to constraints such as staff availability, minimum and maximum group sizes, and timetabling factors as well as a student's ability to meet any pre-requisite rules.