CE40130: Advanced bioprocessing in tissue engineering
[Page last updated: 06 September 2022]
| Academic Year: | 2022/23 |
| Owning Department/School: | Department of Chemical Engineering |
| Credits: | 6 [equivalent to 12 CATS credits] |
| Notional Study Hours: | 120 |
| Level: | Masters UG & PG (FHEQ level 7) |
| Period: |
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| Assessment Summary: | EX 100% |
| Assessment Detail: |
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| Supplementary Assessment: |
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| Requisites: | |
| Learning Outcomes: | On successful completion of this unit students should be able to:
* Select and explain biological conditions as relevant to tissue engineering applications, * Critically evaluate biological data to inform the design of tissue engineering-based products, * Identify and apply appropriate mathematical models to design and analyse tissue engineering systems, * Propose and justify the design of tissue engineering tools, products or treatments, by inventing new- or adapting and modifying available designs. |
| Aims: | To develop students' ability to apply chemical engineering principles to design challenges in bioprocessing with a focus on tissue engineering applications. |
| Skills: | Acquisition of biological data and interdisciplinary technical information [T,F,A]
Critical assessment and selection of relevant biological data and interdisciplinary technical information [T,F,A] Application of chemical engineering to bioprocess design challenges, applied to tissue engineering [T,F,A] Team work [T,F]. |
| Content: | This unit will study tissue engineering across the scales from the cell-biomaterial interface, to bioreactor design, to system design, with the goal of designing efficient tissue engineering systems.
This unit utilizes a combination of traditional lectures and group work sessions. Review of basic human cell biology. Shear stress effects on cell morphology, signal transduction and mass transfer. Control of cell function by the extracellular matrix and soluble growth factors (tissue microenvironments). Scaffolds/substrates design and characterisation for tissue engineering, interaction of cells with artificial substrates. Fluid mechanical effects on cellular function: devices and methodology used for in-vitro systems. Stem cell engineering and scaffold/substrate effects. Basic principles of cell adhesion, principles of cell migration. Mathematical models for bioreactor design. Bioreactor design for different tissue engineered products. |
| Programme availability: |
CE40130 is Optional on the following programmes:Department of Chemical Engineering
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