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BB20018: Enzymology

[Page last updated: 23 April 2021]

Academic Year: 2021/2
Owning Department/School: Department of Biology & Biochemistry
Credits: 6      [equivalent to 12 CATS credits]
Notional Study Hours: 120
Level: Intermediate (FHEQ level 5)
Period:
Semester 2
Assessment Summary: EX 80%, PR 20%
Supplementary Assessment:
Like-for-like reassessment (where allowed by programme regulations)
Requisites: Before taking this module you must ( take BB10003 AND take 1 MODULE FROM {BB10004, BB10121} ) OR take BB10263
Aims: To provide a fundamental understanding of enzymes as catalysts, at a physio-chemical level, and to relate these molecular properties to their cellular functions.

Learning Outcomes: After taking this course the student should be able to:
* describe the relationship between protein structure, ligand binding and enzyme catalysis;
* explain how enzymes achieve their high catalytic rates;
* explain steady-state kinetics of enzyme-catalysed reactions, the nature of reversible inhibition, and the effects of temperature and pH;
* describe and carry out the requirements of reliable enzyme assays;
* explain allosteric regulation in the control of enzymes;
* describe the organisation of cellular enzymes into multienzyme complexes and multifunctional enzymes;
* describe the role of isoenzymes in cellular regulation, development and differentiation, and their application to diagnosis of disease;
* describe and explain the role of coenzymes in enzyme catalysis.

Skills: Learning and studying T/F/A, Written communication T/F/A, Numeracy & computation T/F/A, Laboratory skills T/F, Information technology T/F, Problem solving T/F, Information handling & retrieval T/F/A, Working independently T/F, Career preparation T/F.

Content: Ligand binding; steady-state kinetics; inhibition; effects of temperature and pH; principles of enzyme assay; theories of catalysis; allostery; isoenzymes, multienzyme complexes; coenzyme chemistry.

Programme availability:
NB. Postgraduate programme information will be added when the postgraduate catalogues are published in August 2021

BB20018 is Compulsory on the following programmes:

Department of Biology & Biochemistry
  • USBB-AFB02 : BSc(Hons) Biochemistry (Year 2)
  • USBB-AKB06 : BSc(Hons) Biochemistry with Professional Placement (Year 2)
  • USBB-AFM06 : MBiochem(Hons) Biochemistry (Year 2)
  • USBB-AKM06 : MBiochem(Hons) Biochemistry with Professional Placement (Year 2)
Programmes in Natural Sciences
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Biochemistry with Chemistry stream) (Year 2)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Biochemistry with Chemistry stream) with Study year abroad (Year 2)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Biochemistry with Chemistry stream) with Year long work placement (Year 2)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Biochemistry with Environmental Science stream) (Year 2)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Biochemistry with Environmental Science stream) with Study year abroad (Year 2)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Biochemistry with Environmental Science stream) with Year long work placement (Year 2)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Biochemistry with Pharmacology stream) (Year 2)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Biochemistry with Pharmacology stream) with Study year abroad (Year 2)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Biochemistry with Pharmacology stream) with Year long work placement (Year 2)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Chemistry with Biochemistry stream) (Year 2)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Chemistry with Biochemistry stream) with Study year abroad (Year 2)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Chemistry with Biochemistry stream) with Year long work placement (Year 2)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Environmental Science with Biochemistry stream) (Year 2)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Environmental Science with Biochemistry stream) with Study year abroad (Year 2)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Environmental Science with Biochemistry stream) with Year long work placement (Year 2)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Pharmacology with Biochemistry stream) (Year 2)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Pharmacology with Biochemistry stream) with Study year abroad (Year 2)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Pharmacology with Biochemistry stream) with Year long work placement (Year 2)
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Biochemistry with Chemistry stream) (Year 2)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences (Biochemistry with Chemistry stream) with Study year abroad (Year 2)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences (Biochemistry with Chemistry stream) with Professional Placement (Year 2)
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Biochemistry with Pharmacology stream) (Year 2)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences (Biochemistry with Pharmacology stream) with Study year abroad (Year 2)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences (Biochemistry with Pharmacology stream) with Professional Placement (Year 2)
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Chemistry with Biochemistry stream) (Year 2)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences (Chemistry with Biochemistry stream) with Study year abroad (Year 2)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences (Chemistry with Biochemistry stream) with Professional Placement (Year 2)

BB20018 is Optional on the following programmes:

Department of Biology & Biochemistry
  • UXXX-AFB11 : BSc(Hons) Biomedical Sciences (Year 2)
  • UXXX-AKB11 : BSc(Hons) Biomedical Sciences with Professional Placement (Year 2)
  • UXXX-AFM11 : MBioMed(Hons) Biomedical Sciences (Year 2)
  • UXXX-AKM11 : MBioMed(Hons) Biomedical Sciences with Professional Placement (Year 2)
Programmes in Natural Sciences
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Chemistry with Environmental Science stream) (Year 2)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Chemistry with Environmental Science stream) with Study year abroad (Year 2)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Chemistry with Environmental Science stream) with Year long work placement (Year 2)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Chemistry with Pharmacology stream) (Year 2)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Chemistry with Pharmacology stream) with Study year abroad (Year 2)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Chemistry with Pharmacology stream) with Year long work placement (Year 2)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Environmental Science with Chemistry stream) (Year 2)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Environmental Science with Chemistry stream) with Study year abroad (Year 2)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Environmental Science with Chemistry stream) with Year long work placement (Year 2)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Pharmacology with Chemistry stream) (Year 2)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Pharmacology with Chemistry stream) with Study year abroad (Year 2)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Pharmacology with Chemistry stream) with Year long work placement (Year 2)
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Chemistry with Pharmacology stream) (Year 2)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences (Chemistry with Pharmacology stream) with Study year abroad (Year 2)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences (Chemistry with Pharmacology stream) with Professional Placement (Year 2)

Notes:

  • This unit catalogue is applicable for the 2021/22 academic year only. Students continuing their studies into 2022/23 and beyond should not assume that this unit will be available in future years in the format displayed here for 2021/22.
  • Programmes and units are subject to change in accordance with normal University procedures.
  • Availability of units will be subject to constraints such as staff availability, minimum and maximum group sizes, and timetabling factors as well as a student's ability to meet any pre-requisite rules.
  • Find out more about these and other important University terms and conditions here.