All businesses in the UK will be affected by Brexit, but not all will be affected in the same ways, nor are they all equally able to influence the Government’s negotiating position. This Policy Brief presents findings from discussions with regional business stakeholders in Wales and the South-West, which highlight obstacles to an effective regional lobbying strategy on Brexit. Large companies and manufacturers across the UK have been active in putting across their preferences for arrangements with Europe that replicate the status quo, advocating for permanent membership of a customs union and continued participation in the EU single market. Smaller firms, by contrast, are focusing on their dayto-day operations and are waiting for Government instructions on what to do.