Laboratory visit 1 (around 1 - 1.5 hours):
The visit will involve body measurements, collection of breath samples, and a 15-minute treadmill walk while measuring your heart rate and breathing.
Monitoring phase (2 weeks):
Monitoring of your current lifestyle through wearable devices (such as a smartwatch, activity monitor and a continuous glucose monitor), food diaries and mobile applications.
Laboratory visit 2 (around 7.5 hours):
We will start with body measurements, a body composition scan and collection of breath samples. A fat sample will then be collected, and a cannula will be inserted into a vein so we can collect blood samples throughout the day. You will then be asked to eat a breakfast meal (oatmeal with cream and sugar) drink after which we will regularly collect blood and breath samples for 5 hours, and ask you to complete a few questionnaires.
Dietary phase (4 weeks):
We will ask you to follow one of the following diets for 4 weeks:
1) Restriction of carbohydrates on two days in a row each week
2) Restriction of carbohydrates after 4pm each day
3) No changes to your current diet
You will also be asked to continue monitoring your lifestyle throughout.
Laboratory visit 3 (around 7.5 hours):
Identical as visit 2.
Digital phase (4 weeks):
We will ask you to test out a mobile health-tracking application (‘Metabolism’) that provides education and recommendations tailored specifically to you, while continuing to monitor your lifestyle using a continuous glucose monitor and smartwatch.
Laboratory visit 4 (around 1.5 hours):
The visit will involve body measurements, a body composition scan, a measure of blood pressure, and collection of a single blood sample. Afterwards, we will carry out a 30-minute interview about your experience using the mobile health application.